Phenotype frequencies of blood group systems and alloantibodies to red blood cells in blood transfusion recipients in Kayseri (Turkey)
Yasemin Altuner Torun1, Leylagul Kaynar2, Cigdem Karakukcu3, Mehmet Yay4, Ayse Betul Ergul5, Cem Turanoglu5, Mustafa Cetin2, Bulent Eser2
1Department of Pediatric Hematology, Kayseri Tranining and Research Hospital, Kayseri, Turkey
2Erciyes University School of Medicine Department of Hematology, Kayseri, Turkey
3Department of Biochemistry, Kayseri Tranining and Research Hospital, Kayseri, Turkey
4Erciyes University Medical Faculty Blood Center, Kayseri, Turkey
5Department of Pediatrics, Kayseri Tranining and Research Hospital, Kayseri, Turkey
Aim: In this study, we aimed to asses the antigen and phenotype frequencies of various blood groups among recipients of erythrocyte suspensions in Kayseri.
Materials and Methods: The study was conducted as retrospective, cross sectional and multicenter study. In all, 48750 blood recipients old typed in terms of the ABO, Rh, MNS, Duffy, Lewis, P, Kell, Lutheran, and Kidd systems were subjected to erythrocyte phenotyping using a gel centrifugation method within the age group of 18-60 years.
Results: Of the ABO blood group, A was most frequent (44%) followed by O, B, and AB (30.3%, 16.2%, and 6.5%, respectively). The frequencies of Rh antigens were 88% D-positive and 12% D-negative. Alloantibodies were detected by screening in 196 (0.4%) of 48,750 patients, and decreased in the order anti-E (62%), -C (43%), -D (42%), -C (11%), -c (11%), -e (8%), -M (7%), -Fy a (5%), -Jk a (5%), -Kp a (4%), -Le a (3%), -Jk b (2%) ,-S (2%), -Le b (1%), and -P (1%). The most frequently detected alloantibodies were anti-E (31.6%) and -K (21.9%).
Conclusion: Knowledge of the phenotypic frequencies of red blood cell antigens allows the creation of banks of appropriate antigen-negative blood, thus preventing transfusion reactions in patients requiring multiple transfusions or who express alloantibodies.
Keywords: Blood Group Systems; Alloantibody; Kayseri; Phenotype Frequency.